血管内皮生长因子D在肺腺癌免疫治疗反应中的作用
Xiaoling Du1,2, Sha Yang1, Jiaojiao Bian1
1Department of Pharmacy, North Sichuan Medical College Nanchong 637000, Sichuan, P. R. China.
American journal of translational research
|July 15, 2024
概括
血管内皮生长因子D (VEGFD) 与先天性免疫有关,并预测肺腺癌 (LUAD) 的预后. 在LUAD患者中,VEGFD还可以预测抗PD-1免疫疗法的反应.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 与瘤相关的巨细胞 (TAMs) 在瘤进展和免疫规避中发挥着至关重要的作用.
- 了解与TAM相关的遗传情景对于开发有效的肺腺癌 (LUAD) 疗法至关重要.
- 识别免疫疗法反应的生物标志物可以改善患者的治疗结果.
研究的目的:
- 在LUAD预后中识别与TAM和瘤免疫疗法相关的关键基因.
- 建立基于TAM相关基因的LUAD预后风险模型.
- 验证已识别的基因在免疫治疗反应中的预测作用.
主要方法:
- 使用了癌症基因组图谱 (TCGA) 数据库用于LUAD mRNA表达特征.
- 雇佣了CIBERSORT来分析免疫细胞透和WGCNA,LASSO和Cox回归来构建风险模型.
- 在IMvigor210队列中验证的发现和使用的组织微阵列和免疫光染色.
主要成果:
- 确定了 LUAD 和正常组织之间的先天性免疫细胞的显著差异.
- 发现了四个枢纽基因,包括血管内皮生长因子D (VEGFD),作为独立的预后风险因素.
- VEGFD是一个低风险因素,与更好的LUAD预后和对抗PD-L1疗法的更高敏感性有关.
结论:
- 在LUAD中,VEGFD与先天性免疫显著相关.
- VEGFD可以作为LUAD预后的预测生物标志物.
- 在LUAD患者中,VEGFD显示出作为抗PD-1治疗疗效的预测因素的潜力.
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