在各种类型的帕金森病中,前额皮层和补充运动区域之间的连接性发生变化
Fengbo Xing1,2,3, Jingjing Feng1,2,3, Lingling Lv1,2,3
1Department of Neurology, The First Affiliated Hospital of Anhui Medical University Hefei 230000, Anhui, China.
American journal of translational research
|July 15, 2024
概括
帕金森病的亚型显示出不同的大脑连接模式. 额叶皮层-SMA连接减少的特点是PIGD,而视听网络变化标志着TD.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 帕金森病 (PD) 呈现出像震主导 (TD) 和姿势不稳定/走路困难 (PIGD) 这样的亚型.
- 对于TD和PIGD亚型,存在不同的临床特征和预后.
- 区分PD亚型的潜在神经机制尚未完全理解.
研究的目的:
- 调查前皮层和补充运动区域 (SMA) 的功能连接的改变.
- 在震主导 (TD) 和姿势不稳定/走路困难 (PIGD) 之间区分神经机制.帕金森病亚型.
主要方法:
- 对173名参与者的静止状态功能性MRI (rs-fMRI) 数据的回顾性分析 (41名TD,65名PIGD,67名对照).
- 低频波动 (ALFF) 的比较幅度,音频智能功能连接 (FC) 和跨组功能网络连接 (FNC).
- 利用部分相关性分析将大脑活动与临床分数联系起来.
主要成果:
- 与对照组相比,PIGD和TD患者均表现出左侧脊侧上额头 (DLSFG) ALFF的增加.
- 在PIGD患者的左侧DLSFG和左侧SMA之间观察到降低的FC,与PIGD严重程度相关.
- 在TD患者中发现视听网络 (VN-AUD) 连接性减少,与震严重程度相关.
结论:
- 左侧DLSFG-SMA连接性下降是帕金森病PIGD亚型的潜在神经标记物.
- 视听网络连接的减少可能是震主导亚型的特征.
- 这些发现突出了主要帕金森病亚型的独特的神经生物学基础.
相关概念视频
Parkinson's Disease: Treatment
251
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
251
Parkinson's Disease: Overview
522
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
522
Neural Regulation
39.3K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.3K
Motor and Sensory Areas of the Cortex
3.7K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
3.7K
Role of Cerebellum and Prefrontal Cortex in Memory
413
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
413


