自作为乳腺瘤的治疗目标:癌症干细胞的视角
Sana Raza1, Jawed Akhtar Siddiqui2, Anubhav Srivastava3
1Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
Autophagy reports
|July 15, 2024
概括
乳腺癌干细胞 (BCSCs) 利用自为生存和治疗耐药性. 准自途径为乳腺癌治疗提供了一个潜在的治疗策略.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 分子医学是分子医学.
背景情况:
- 乳腺癌是一种由异质瘤细胞驱动的复杂疾病,包括乳腺癌干细胞 (BCSCs).
- 瘤微环境 (TME) 显著影响癌症进展和治疗反应.
- 自,细胞降解过程,在乳腺TME中起着双重作用,影响瘤的发展和异质性.
研究的目的:
- 提供一篇关于自和乳腺癌干细胞 (BCSCs) 之间的复杂关系的综合性审查.
- 要突出最近在理解自和BCSCs之间的相互作用方面取得的进展.
- 讨论在乳腺癌治疗中准自的治疗潜力.
主要方法:
- 对专注于自,BCSC和乳腺癌的科学文章的文献综述.
- 分析调节BCSC中自的分子机制,包括关键信号通路.
- 检查当前的临床前和临床发展的自性向剂.
主要成果:
- 自促使乳腺瘤发生,通过支持BCSC的干部,生存,迁移,入侵,代谢重编程和上皮-介质细胞过渡 (EMT).
- BCSC利用自来抵抗治疗并逃避免疫监测.
- 失调或过度的自可以诱导BCSC的分化或细胞死亡,这表明治疗的脆弱性.
结论:
- 自是乳腺癌干细胞行为和治疗耐药性的关键调节者.
- 针对自途径,如mTOR,AMPK和Beclin-1,为乳腺癌提供了有前途的治疗策略.
- 针对自细胞向剂的进一步研究和临床开发是有效治疗乳腺癌的必要条件.
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