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在肌内注射孕激素后,在冷解胚胎移植中,个性化形阶段支持可能会纠正活产率

Fazilet Kübra Boynukalin^1,2, Yusuf Aytac Tohma^3,4, Zalihe Yarkıner⁵

¹Infertility Department, Bahçeci Fulya IVF Center, Istanbul, Türkiye.

Frontiers in endocrinology

|July 15, 2024

概括

对于胚胎移植日血清孕激素低的妇女,使用阴道孕激素的救援方案在冷融化胚胎移植周期中没有影响活产率. 这一发现表明,目前的救援方案可能不需要改善妊娠结果.

科学领域:

生殖内分泌学生殖内分泌学
不孕症研究不孕症研究
胚胎移植协议胚胎移植协议

背景情况:

血清孕激素水平对于妊娠结果至关重要,但最佳的质期切断值仍在争论中.
有限的研究存在于有限的研究.
救援协议,救援协议.
对于低孕激素,特别是使用肌内孕激素 (IM-P) 在冷解胚胎移植 (FET) 中.

研究的目的:

在使用IM-P的FET周期期间,评估一个涉及阴道孕激素的救援协议的有效性,用于在胚胎移植日低血清孕激素水平的患者.
为了确定这个救援协议是否会影响临床怀孕,流产或活产率.

主要方法:

用人工制备的子宫内膜和100毫克IM孕激素对637个FET周期进行了回顾性队列研究.
在第一次IM-P剂量后117-119小时和最后一剂量后21±2小时测量了血清孕激素.
胚胎移植当天血清孕激素<20.6ng/ml的患者接受了400毫克的阴道孕激素作为救援干预.

主要成果:

在接受救援性阴道孕激素和未接受治疗的组之间,在临床怀孕率 (52.9%与59.6%),流产率 (11.1%与14.1%) 或活产率 (47.1%与50.7%) 中没有显著差异.
女性年龄和胚胎质量被确定为活产的独立预测因素.
胚胎移植当天的血清孕激素水平在实施救援协议后并不是活产的重要预测因素.

结论:

救援性阴道孕激素用于胚胎移植日血清孕激素度较低的肌肉内孕激素后的救援性阴道孕激素不改善活产率.
这些发现表明,目前的救助方案可能对改善FET周期中的妊娠结果没有好处.

关键词:

在冷胚胎转移过程中,激素替代疗法是一种激素替代疗法.肌肉内注射的孕激素可以形阶段的支持.救援孕激素孕激素的救援

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