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最近在水性双相系统的药物输送应用中的进展
Mojhdeh Baghbanbashi1, Hadi Shaker Shiran2, Ashok Kakkar3
1Department of Agricultural and Biological Engineering, Purdue University, 610 Purdue Mall, West Lafayette, IN 47907, USA.
PNAS nexus
|July 15, 2024
概括
水性双相系统 (ATPS) 提供了一个安全的,富含水的环境,用于创建纳米粒子和微粒子等药物输送载体. 这些系统可以有效地加载生物分子,用于先进的治疗应用.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 水性双相系统 (ATPS) 定义为富含水分 (>70%的水) 的液态相中的液体-液体平衡.
- 它们提供了一个生物相容,无有机溶剂的介质,非常适合处理敏感的生物分子.
- 越来越多地探索ATPS来制定先进的药物输送系统.
研究的目的:
- 审查ATPS在生物活性材料载体配方中的多种应用.
- 分析ATPS中粒子形成,聚合和组装的策略.
- 总结和讨论ATPS在药物输送中的使用.
主要方法:
- 分析各种ATPS组合物及其相分离特性.
- 在ATPS中审查粒子形成技术 (微粒子,纳米粒子,水凝,聚合体).
- 检查各种生物活性有效载荷 (药物,蛋白质,细胞) 的加载方法和聚合策略.
主要成果:
- 通过相分离驱动的ATPS促进载体的自发形成.
- 对于粒子制造,存在各种策略,包括滴滴聚合和相导块共聚合物组装.
- 可以将小分子药物,蛋白质和细胞有效地装入ATPS衍生的载体.
结论:
- ATPS是开发具有可调节性质的新型药物输送载体的多功能平台.
- 由于ATPS的生物相容性,它们适用于敏感的生物分子和治疗应用.
- 对刺激反应的载体和先进的加载技术的进一步研究对药物输送具有重大前景.
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