周围循环中高的特定促炎细胞因子表明,在粉红中,焦虑和抑郁的风险增加
Xiaoting Yang1, Zuxing Feng2, Mei Cai1
1Department of Dermatology and Venereology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, People's Republic of China.
Journal of inflammation research
|July 15, 2024
概括
增加的益炎性细胞因子IL-1β,IL-17和IL-8与粉红病患者的焦虑和抑郁有关. 这些发现表明,粉红和心理健康状况之间有共同的炎症途径.
科学领域:
- 皮肤病学和精神病学
- 免疫学 免疫学 免疫学
- 医学研究 医学研究
背景情况:
- 促炎性细胞因子在粉红,焦虑和抑郁症中起作用.
- 了解这些疾病之间的联系对于有效治疗至关重要.
研究的目的:
- 通过检查促炎性细胞因子水平来调查粉红病,焦虑和抑郁之间的关系.
- 为了确定潜在的常见炎症机制.
主要方法:
- 分析了280名粉红患者,210名精神障碍患者和70名健康对照者的血清样本.
- 酶相关免疫吸收试验 (ELISA) 用于测量关键的促炎细胞因子.
- 统计分析包括奇方位,克鲁斯卡尔-瓦利斯H测试,通用线性模型和二进制后勤回归.
主要成果:
- 与健康对照组相比,IL-1β,IL-17和IL-8的水平在粉红和焦虑/抑郁组显著更高 (P<0.001).
- 与健康对照组相比,TNF-α水平在粉红患者中升高 (P<0.001).
- 在IL-1β,IL-17和IL-8水平 (P<0.001) 之间观察到粉红病,焦虑和抑郁症之间的显著相互作用.
- 增加的IL-1β,IL-17和IL-8与粉红患者的焦虑和抑郁正相关 (P<=0.05).
结论:
- 升高的IL-1β,IL-17和IL-8水平与粉红病患者的焦虑和抑郁正相关.
- 这些发现表明,常见的炎症机制是粉红和精神障碍的共同发生的基础.
- 鉴于TNF-α在粉红患者中的特异性升高,TNF-α可能是粉红的潜在治疗标.
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