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维生素D结合蛋白:老年COVID-19急性肺损伤的潜在因素

Hongjuan Jiang¹, Xiangyu Chi¹, Yanhong Sun¹

¹Department of Geriatric Respiratory Disease, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China.

Journal of inflammation research

|July 15, 2024

概括

维生素D结合蛋白 (VDBP) 水平升高与COVID-19患者的急性肺损伤 (ALI) 有关. 在肺上皮细胞中,VDBP促进炎症和细胞死亡,这表明它是潜在的治疗点.

科学领域:

免疫学免疫学免疫学
肺部病理学肺部病理学
分子生物学分子生物学

背景情况:

维生素D结合蛋白 (VDBP) 以其在炎症和组织损伤中的作用而闻名.
与COVID-19相关的急性肺损伤 (ALI) 中VDBP的具体参与仍未得到充分研究.
这项研究旨在澄清VDBP在COVID-19相关ALI中的作用.

研究的目的:

为了比较COVID-19患者的血清VDBP水平与没有ALI.
使用细胞模型研究VDBP在ALI炎症过程中的功能作用.
探索VDBP作为潜在的生物标志物和治疗点在COVID-19相关的ALI.

主要方法:

在COVID-19患者中测量了血清VDBP度.
在人类膜上皮细胞A549细胞中进行了VDBP基因沉默.
用脂聚糖 (LPS) 刺激细胞以模仿ALI条件.
评估了炎症标志物 (IL-1β,TNF-α),细胞活力 (CCK-8) 和亡.

主要成果:

在患有ALI的COVID-19患者中,血清VDBP水平显著更高.
血清VDBP与诸如C反应蛋白和IL-6之类的炎症标志物正相关.
血清VDBP增加被确定为COVID-19中ALI的独立风险因素.
在LPS刺激的A549细胞中,VDBP基因沉默减少了炎症性细胞因子的释放,并降低了细胞亡.
在沉默VDBP表达的细胞中,细胞活力得到增强.

结论:

在COVID-19患者中,急性肺损伤与血清VDBP度升高有关.
VDBP似乎促进支气管上皮细胞的炎症反应和亡.
这些发现凸显了VDBP在COVID-19相关ALI的发病过程中的重要作用.

关键词:

在 COVID-19 疫情中,维生素D结合蛋白是一种维生素D结合蛋白.肺部急性肺损伤是什么病变的发生和发病.

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