肝脏疾病作为结肠直肠癌的潜在危险因素:社区医院的经验
Daniel Aillaud-De-Uriarte1,2, Luis A Hernandez-Flores2, Philip N Zachariah3
1Center for Bioethics, Harvard Medical School, Boston, USA.
Cureus
|July 15, 2024
概括
肝病显著增加结直肠癌的风险,特别是在女性. 在肝病患者中,早期对结直肠癌的查可能是有益的.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 肝病 (LD) 是一种普遍的疾病,通常无症状.
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题.
- 新出现的证据将肝炎与结直肠癌的发展联系在一起.
研究的目的:
- 调查先前存在的肝病与结直肠癌风险之间的关联.
- 通过性别,种族和种族来分析这种关联的潜在差异.
主要方法:
- 一项为期五年的 (2018-2022) 病例控制研究,对274名CRC和腺瘤患者进行了研究.
- 对先前存在的肝脏疾病 (如肥胖症,肝硬化,病毒性肝炎) 的医疗记录的审查.
- 使用奇二测试和双项逻辑回归 (p < 0.05 显著性) 的统计分析.
主要成果:
- 患有肝病的患者患结直肠癌的几率翻了一番 (OR 2.13-2.30).
- 肝病和结直肠癌之间的关联在女性 (p = 0.018) 比男性 (p = 0.056) 更强.
结论:
- 肝病是结直肠癌的重要危险因素,特别是在女性中.
- 进一步的研究应该探索机制,早期查在LD患者的实用性,以及干预影响.
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