内分泌药物输送中的新兴技术:为改善患者护理的创新
Mahvish Renzu1, Carly Hubers2, Kendall Conway2
1Internal Medicine, Trinity Health Oakland/Wayne State University, Pontiac, USA.
Cureus
|July 15, 2024
概括
先进的药物输送系统,包括可穿戴的人工胰腺和微针贴片,通过改善患者的治疗结果和坚持,正在改变内分泌疾病的治疗. 这些创新为传统方法提供了更安全,更有效的激素治疗替代方案.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 对于内分泌系统疾病,传统的口服和注射药物输送带来了诸如不良坚持和副作用等挑战.
- 最近的技术进步为克服这些局限性提供了新的解决方案.
研究的目的:
- 对内分泌疾病的先进药物输送系统的临床疗效,安全性和局限性进行审查和分析.
- 突出这些技术在个性化医疗和改善患者治疗结果方面的潜力.
主要方法:
- 关于内分泌疾病的创新药物输送技术的最新文献的审查.
- 对非侵入性 (吸入胰岛素,机器人药片,微针贴片),半侵入性 (植入式设备) 和可穿戴系统 (人工胰腺,智能胰岛素笔) 的分析.
- 评估临床数据的疗效,安全性,患者遵守和副作用的概况.
主要成果:
- 吸入胰岛素和机器人药丸提供了更好的吸收和服从.
- 可穿戴的人工胰腺系统显示出优越的血糖控制和降低低血糖.
- 微针贴片和可植入装置提供最小侵入性或长期控制的药物释放,增强坚持.
- 智能胰岛素笔通过数据跟踪和共享来改善糖尿病管理.
结论:
- 先进的药物输送系统显著提高了患者的治疗结果和治疗内分泌疾病的坚持.
- 这些技术代表着向个性化医疗的转变,为个体需求量身定制治疗.
- 进一步的研究和这些系统的整合有望为彻底改变内分泌疾病管理带来革命.
相关概念视频
01:16Drug Delivery: Overview
285
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
285
01:18Drug Delivery: Enteral Route
415
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
415
01:22Drug Delivery: Miscellaneous Routes
336
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
336
01:29Drug Delivery: Parenteral Route
476
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
476
01:29Issues And Trends In Healthcare Delivery System
5.6K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.6K
01:18Routes of Drug Administration: Enteral
3.4K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
3.4K