从第一到第二季度的子宫 - 胎盘输液发育的比较,低风险和高风险的预先黄昏症组与阿司匹林预防之间的比较
Jochen Ritgen1, Julia Roxin2, Marit Kolsch1
1Center for Prenatal Medicine and Genetics, Praenatal Plus, Cologne, DEU.
Cureus
|July 15, 2024
概括
阿司匹林预防可能会降低子前风险. 在怀孕早期持续的刺痕和高的子宫动脉脉动指数 (UtAPI MoM) 是早期出现子宫前的危险因素.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 怀孕中的心血管生理学
背景情况:
- 孕前 (PE) 是一个重要的全球妊娠并发症,早期发病的PE具有严重的风险.
- 在妊娠16周之前开始的低剂量阿司匹林 (150毫克/天) 预防可以减轻PE风险.
研究的目的:
- 评估母亲因素对子宫胎盘输液和胎儿生物学的影响.
- 在接受阿司匹林预防的高风险组与低风险对照组中比较这些参数.
主要方法:
- 一项病例控制研究,涉及448名PE高风险妇女 (阿司匹林组) 和468名低风险妇女 (对照组).
- 母亲因素,子宫动脉脉动指数 (UtAPI MoM),切口和胎儿生物识别在第一 (T1) 和第二 (T2) 三季度进行了评估.
主要成果:
- 升高的UtAPI MoM和持续的划痕与增加PE风险有关.
- 预先存在的高血压与UtAPI发展相关,高血压妇女的UtAPI下降较低.
- 与对照组相比,阿司匹林预防组显示出较高的UtAPI MoM和划痕率. 估计的胎儿体重在阿司匹林组较低.
结论:
- 持续的切口和第二个三个月的升高的UtAPI MoM是早期发病PE的潜在危险因素.
- 患有高血压,划痕和UtAPI升高的妇女需要在整个怀孕期间密切监测.
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