目前对化生物制剂暴露对Enterococcus spp的影响的见解
Ana P Pereira1,2, Patrícia Antunes1,2,3, Luísa Peixe1,2
1UCIBIO-Applied Molecular Biosciences Unit, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Frontiers in microbiology
|July 15, 2024
概括
电离生物制剂 (CB) 对于控制菌感染至关重要. 广泛的CB使用可能会导致Enterococcus种群的耐药性,影响生化剂和抗生素的疗效,需要进一步研究公共卫生战略.
科学领域:
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
- 公共卫生 公共卫生
背景情况:
- 包括四级化合物和大化物在内的化生物制剂 (CBs) 对于控制细菌病原体至关重要.
- 肠球菌 (Enterococcus spp.) 是一种细菌. 是多抗药性医疗保健相关感染的主要原因.
- 广泛的CB使用引发了人们对Enterococcus产生抗生素和抗生素耐药性的担忧,这是由于暴露于亚抑制度.
研究的目的:
- 探索肠球菌对CBs的反应的复杂性.
- 调查Enterococcus的潜在进化,以抵抗CBs和抗生素.
- 确定了解CB对Enterococcus流行病学影响的知识和方法上的差距.
主要方法:
- 对现有文学进行全面的叙事审查.
- 对各种Enterococcus spp.的CB活性进行分析. 收藏. 收藏. 这些收藏.
- 检查与降低对CBs敏感性相关的基因.
- 评估CB和抗生素之间潜在的共抗和交叉抗性的评估.
主要成果:
- 目前的研究存在重大知识和方法差距.
- 审查强调需要进一步研究CBs对菌体的影响.
- 了解Enterococcus对CBs的反应对于公共卫生至关重要.
结论:
- 持续有效的CBs需要更深入地了解Enterococcus耐药机制.
- 未来的研究应该解决发现的差距,以告知有效的健康战略.
- 保护公共健康需要制定战略,以保持关键生物杀伤剂的有效性.
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