通过使用Pelargonium sidoides的DC提取物在微波辅助绿色合成中增强银纳米颗粒对病原性细菌的抗菌活性
Renata Pascoal Illanes Tormena1, Mac-Kedson Medeiros Salviano Santos1, Atailson Oliveira da Silva1
1Green Nanotechnology Group, University of Brasilia DF 72220-900 Brasilia Brazil mhsousa@unb.br mhsqui@gmail.com.
RSC advances
|July 15, 2024
概括
使用Pelargonium sidoides提取物合成银纳米粒子 (AgNPs) 的绿色合成显示出强大的抗菌活性. 优化的纳米配方有效地向致病细菌,包括耐药菌株.
科学领域:
- 纳米技术纳米技术
- 绿色化学 绿色化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 植物提取物越来越多地用于纳米粒子合成.
- 皮拉戈尼 (Pelargonium sidoides) 根部提取物含有具有潜在生物活性的植物化学物质.
- 银纳米粒子 (AgNPs) 具有广泛的抗微生物特性.
研究的目的:
- 为了优化微波辅助的AgNP的绿色合成,使用Pelargonium sidoides根提取物.
- 为了描述合成的AgNPs.
- 为了评估AgNPs纳米配方的抗菌疗效和细胞毒性.
主要方法:
- 微波辅助合成优化了温度,度和时间.
- 使用XRD,UV-vis,FTIR,XPS和zeta测量进行表征.
- 通过最小抑制度 (MIC) 对黄金葡萄球菌,大肠杆菌, Pseudomonas aeruginosa 和 Klebsiella pneumoniae (KPC) 进行评估的抗菌活性.
- 细胞毒性通过细胞活力测试进行评估.
主要成果:
- 成功合成的AgNP (大约. 17纳米) 具有由植物化合物功能化的金属银芯.
- 纳米配方表现出显著的剂量依赖性抗微生物疗效对测试的病原体.
- MIC值在0.85至17.1μg mL-1之间,显示出对抗抗卡巴胺耐药的Klebsiella肺炎 (KPC) 的显著活性.
- 在生理pH值下,AgNP表现出良好的体稳定性.
结论:
- 优化的微波辅助绿色合成为AgNP提供了一条有效的途径.
- 来自Pelargonium sidoides的AgNP表现出增强的协同抗菌活性.
- 该纳米配方呈现出对抗多药耐药细菌的有前途的治疗剂.
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