跨磁刺激对自闭症儿童睡眠结构和质量的影响
Juan Yan1, Yan Zhang2, Junjie Wang1
1Quality Control Office, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang, China.
Frontiers in psychiatry
|July 15, 2024
概括
低频跨脑磁性刺激 (TMS) 有效地改善了自闭症谱系障碍 (ASD) 儿童的睡眠. 这种非侵入性治疗向了背侧前额叶皮质,在6周后显示出显著的益处.
科学领域:
- 神经科学是一个神经科学.
- 儿科睡眠医学 儿科睡眠医学
- 自闭症谱系障碍研究研究
背景情况:
- 睡眠障碍在患有自闭症谱系障碍 (ASD) 的儿童中很普遍.
- 通过调节神经元刺激性,跨磁刺激 (TMS) 显示出改善睡眠和其他自闭症症状的潜力.
- 关于TMS对ASD相关睡眠障碍的临床机制的研究有限.
研究的目的:
- 研究低频TMS对ASD儿童睡眠结构和质量的影响.
- 为了比较主动TMS与假TMS在治疗ASD睡眠障碍方面的疗效.
主要方法:
- 60名患有自闭症的儿童被随机分配给接受活跃或假的低频率 (0.5Hz) TMS,目标是背侧前额叶皮层,持续6周.
- 30名健康儿童作为对照组.
- 在基线,3周和6周使用儿童睡眠障碍量表 (SDSC) 评估睡眠质量.
主要成果:
- 与对照人群相比,患有自闭症的儿童在多个SDSC子尺度上表现出明显更高的得分.
- 活跃的TMS在30次会议后导致总SDSC得分和特定睡眠参数 (入睡困难,睡眠维持,睡眠-清醒过渡障碍,过度白天嗜睡) 的明显改善,与假TMS相比.
- 活跃的TMS组在6周治疗后,在大多数SDSC维度中显示出明显更高的减少率.
结论:
- 针对背侧前额皮质的低频TMS是一种有效的治疗方法,可以改善ASD儿童的睡眠.
- 在积极的TMS干预6周 (30次) 后,观察到显著的睡眠改善.
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