血清尿酸与肌素比率升高与不良妊娠结果有关:一个前性出生队列研究
Enjie Zhang1, Shaofei Su1, Shen Gao1
1Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital. Beijing, China.
International journal of medical sciences
|July 15, 2024
概括
在怀孕早期,母亲血清尿酸与肌素的比率 (SUA/SCr) 与妊娠期糖尿病和高血压等不良结果的风险增加有关. 监测SUA/SCr可能有助于早期检测和干预,以改善妊娠健康.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 临床化学 临床化学
背景情况:
- 怀孕不良后果对母亲和新生儿的健康构成重大风险.
- 早期识别风险因素对于及时干预至关重要.
- 母乳血清尿酸与肌素比率 (SUA/SCr) 在怀孕早期作为预测因素的作用尚未完全理解.
研究的目的:
- 评估第一季度母亲血清尿酸与肌素的比率 (SUA/SCr) 与母亲和新生儿不良结果之间的关联.
- 调查SUA/SCr对妊娠糖尿病 (GDM) 和妊娠引起的高血压 (PIH) 等疾病的预测价值.
主要方法:
- 从2018年到2021年,一项涉及33030名孕妇的前性出生队列研究进行了.
- 后勤回归模型和受限制的立方线被用来分析SUA/SCr和胎儿-母亲结局之间的关联.
- 根据母亲年龄和怀孕前的体重指数进行分层对子组进行分析.
主要成果:
- 最高的SUA/SCr四分位数与GDM (OR 2.14),PIH (OR 1.79) 剖腹产 (OR 1.24) 和早产 (OR 1.30) 的风险增加有显著关联.
- 在SUA/SCr和不良妊娠结果之间观察到线性关系,除了GDM.
- 在年轻的孕妇中,SUA/SCr和PIH/LGA风险之间的关联更为强烈.
结论:
- 孕妇在头三个月内SUA/SCr水平升高与妊娠不良结果的风险增加有关.
- 在怀孕早期监测SUA/SCr可以帮助识别高风险怀孕.
- 这种监测可以为改善母亲和新生儿健康的有针对性的干预提供基础.
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