孕产妇便秘与后代亚托皮炎风险的关联
Jyun-Yi Guo1, Meng-Che Wu1,2,3,4, Yu-Hsun Wang5
1Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.
International journal of medical sciences
|July 15, 2024
概括
孕产妇便秘与儿童皮炎 (AD) 的风险增加有关. 这项研究发现,母亲在怀孕期间经历了便秘的后代患阿尔茨海默病的风险高出1.26倍.
科学领域:
- 儿科 儿科 儿科
- 皮肤病学 皮肤病学
- 胃肠病学 胃肠病学
背景情况:
- 亚托匹性皮肤炎 (AD) 是一种流行,慢性皮肤疾病,影响所有年龄组,发病率越来越高.
- 便秘是全球普遍存在的问题,可能会影响肠道微生物群,并且已被暂时与阿托皮性疾病联系起来.
- 孕产妇便秘与子女患亚托皮炎的风险之间的关系需要进一步研究.
研究的目的:
- 为了调查母亲便秘与儿童皮炎风险之间的关联.
- 分析母亲便秘对后代患阿尔茨海默病的风险的影响.
主要方法:
- 一项使用台湾国家健康保险研究数据库的回顾性队列研究.
- 138,553名患有便秘的母亲与138,553名使用倾向评分分析的对照进行了1:1匹配.
- 使用多重考克斯回归和子组分析来确定儿童阿尔茨海默病的调整危险比率 (aHR).
主要成果:
- 患有便秘的母亲的孩子患阿尔茨海默病的风险增加了1.26倍 (aHR:1.26;95% CI,1.25-1.28).
- 这种关联在各种子组中保持一致,无论孩子的性别,出生体重,妊娠周,分娩方式或母亲的并发症.
- 母亲更频繁的药处方 (≥12次) 显示出更高的aHR (1.40;95% CI,1.29-1.52) 后代的AD.
结论:
- 孕产妇的便秘与子女发生亚托皮炎的风险增加有显著的关联.
- 医疗保健提供者应该考虑孕产妇便秘作为儿童AD的潜在风险因素.
- 需要进一步的研究,以阐明连接孕产妇便秘和后代无性疾病的潜在机制.
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