在阿波利波蛋白E ɛ4和血管风险因素对加速大脑衰老的影响中的种族差异
Yanghee Im1,2, Sung Hoon Kang3,4, Gilsoon Park1
1USC Steven Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
Brain communications
|July 15, 2024
概括
无脂蛋白E ɛ4等位基因和血管风险因素加速大脑衰老,影响因种族而异. 需要量身定制的策略来解决这些差异在认知正常的个体.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 无脂蛋白E (APOE) ɛ4等位基因是众所周知的各种大脑疾病的风险因素.
- 血管风险因素也显著影响大脑健康.
- 在APOE等位基因频率和血管风险因子患病率的种族差异得到了充分证实.
研究的目的:
- 调查APOE ɛ4和血管风险因素对韩国和英国人口大脑年龄的综合影响.
- 为了确定这些对大脑衰老的综合影响的种族差异.
主要方法:
- 利用了来自2314名认知无障碍的韩国人和6942名英国成年人 (≥45岁) 的脑成像数据.
- 使用倾向得分匹配来创建可比的队列.
- 计算了大脑年龄指数,并分析了APOE基因型 (ɛ4, ɛ2, ɛ3/ɛ3) 和血管风险因素 (年龄,高血压,糖尿病) 作为预测因素.
主要成果:
- 在韩国和英国的两组中,APOE ɛ4载体的脑年龄指数值显著更高.
- APOE基因型对大脑年龄的不良影响因年龄而增大,特别是在韩国人群中.
- 在APOE基因型,年龄和种族以及APOE基因型,高血压和种族之间观察到显著的三向相互作用,这表明在不同人群中存在差异性影响.
- APOE对大脑年龄的影响在韩国队列中的高血压患者中更为明显.
结论:
- APOE ɛ4基因型和血管风险因素相互作用,影响大脑年龄,有显著的种族差异.
- 与APOE ɛ4相关的加速大脑衰老是由种族和血管健康调节的.
- 特定于种族的方法对于缓解APOE ɛ4相关的大脑衰老的风险,认知不受损的个体至关重要.
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