AnXplore:对101个内动脉瘤进行了全面的液体结构相互作用研究
Aurèle Goetz1, Pablo Jeken-Rico1, Ugo Pelissier1
1Computing and Fluids Research Group, CEMEF, Mines Paris PSL, Sophia Antipolis, France.
Frontiers in bioengineering and biotechnology
|July 15, 2024
概括
模拟具有可变形壁的内动脉瘤,与刚性模型相比,揭示了显著的血液动力学差异. 流体结构相互作用 (FSI) 对于准确预测治疗结果至关重要,特别是流量转移支架.
科学领域:
- 生物医学工程 生物医学工程
- 计算流体动力学的流体动力学.
- 医疗成像医学成像
背景情况:
- 内动脉瘤带来严重的破裂风险.
- 计算流体动力学 (CFD) 有助于理解动脉瘤的血液动力学.
- 以前的研究经常将动脉瘤壁模拟为刚性,限制了准确性.
研究的目的:
- 为了研究墙壁可变性对内动脉瘤血液动力学的影响.
- 将刚性墙模拟与流体结构相互作用 (FSI) 模型进行比较.
- 分析血液动力学变化及其对风险指标的影响.
主要方法:
- 使用刚性和可变形壁模型模拟了101个内侧壁动脉瘤.
- 采用流体结构相互作用 (FSI) 来考虑墙壁的合规性.
- 统计分析了一系列血液动力学模式和风险指标.
- 模拟的流量调节器支架放置使用FSI与合规的墙壁.
主要成果:
- 与刚性模型相比,可变形墙模拟显示了流动特征的显著偏差.
- 圆顶附近的血液循环受到脉动墙壁动态的显著影响.
- 袋式平均振荡切割指数 (OSI) 显示了与FSI的实质性波动 (-36%至+674%).
- 与刚性模型相比,使用流量转移器支架的FSI显示了缩囊平均速度的73%增加.
结论:
- 墙壁建模选择显著影响内动脉瘤的血液动力学预测.
- 流体结构相互作用 (FSI) 对于准确评估血液动力学和风险至关重要.
- FSI建模对于预测流量转移支架等治疗方法的疗效至关重要.
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