Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

30.4K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.4K
Inflammation01:38

Inflammation

53.3K
Overview
53.3K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

25.0K
Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
25.0K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
Structure of Lipids03:38

Structure of Lipids

87.7K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
87.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

AMPK agonism optimizes the in vivo activation and antileukemic efficacy of chimeric antigen receptor T cells.

Journal for immunotherapy of cancer·2025
Same author

p95HER2, a truncated form of the HER2 oncoprotein, drives an immunosuppressive program in HER2<sup>+</sup> breast cancer that limits trastuzumab deruxtecan efficacy.

Nature cancer·2025
Same author

One Step Ahead: Preventing Tumor Adaptation to Immune Therapy.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting·2025
Same author

DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response.

Journal of immunology (Baltimore, Md. : 1950)·2025
Same author

Nuclear receptor 4A1 is critical for neutrophil-dependent pulmonary immunity to <i>Klebsiella pneumoniae</i> infection.

Frontiers in immunology·2025
Same author

Multiplex targeting of immune-modulating genes in cancer.

Nature immunology·2025

相关实验视频

Updated: Jun 21, 2025

Measurement of Fatty Acid &#946;-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
11:03

Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes

Published on: September 9, 2021

3.9K

脂肪酸氧化在免疫功能中的作用

Felicia Kemp1, Erica L Braverman1, Craig A Byersdorfer1

  • 1Department of Pediatrics, Division of Blood and Marrow Transplant and Cellular Therapies, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Frontiers in immunology
|July 15, 2024
PubMed
概括

细胞代谢决定免疫细胞的功能,影响健康和疾病. 了解免疫细胞中的脂肪酸氧化 (FAO) 是开发针对各种疾病的向治疗的关键.

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞的新陈代谢
  • 生物化学 生化学

背景情况:

  • 细胞代谢极大地影响免疫细胞的命运,激活,分化和功能.
  • 代谢失调与自身免疫性疾病,非免疫性,癌症有关,并影响采用细胞治疗的结果.
  • 免疫细胞的代谢途径是多样化的,根据细胞类型,子集和微环境而异.

研究的目的:

  • 审查免疫细胞中主要的代谢途径.
  • 专注于脂肪酸氧化 (FAO) 在不同免疫细胞子集中的特定作用.
  • 突出了解免疫细胞对治疗干预的代谢要求的重要性.

主要方法:

  • 在免疫学中对细胞代谢的文献综述.
  • 分析脂肪酸氧化 (FAO) 在各种免疫细胞类型中的作用.
  • 综合当前对免疫代谢及其治疗影响的理解.

主要成果:

  • 免疫细胞的新陈代谢具有高度适应性和细胞特异性.
  • 脂肪酸氧化 (FAO) 起到多方面的作用,有助于促进和抗炎免疫反应.
  • 代谢途径,特别是粮农组织,对于优化不同环境中的免疫细胞功能至关重要.
关键词:
采用细胞疗法的人.脂肪酸氧化 (FAO) 的方法免疫细胞分化免疫细胞分化免疫代谢的免疫代谢.代谢适应 代谢适应代谢失调是代谢失调的原因之一.

更多相关视频

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

239
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.2K

相关实验视频

Last Updated: Jun 21, 2025

Measurement of Fatty Acid &#946;-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
11:03

Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes

Published on: September 9, 2021

3.9K
Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

239
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.2K

结论:

  • 定制治疗策略需要深入了解免疫细胞子集的独特代谢需求.
  • 向脂肪酸氧化 (FAO) 是调节免疫反应和治疗疾病的有希望的途径.
  • 对免疫代谢的进一步研究将使更有效的细胞疗法和疾病管理成为可能.