血红蛋白,白蛋白,淋巴细胞计数,血小板计数 (HALP) 评分和2型糖尿病视网膜病变之间的关系
Shuqi Wang1,2, Boying Jia1,2, Sifan Niu2,3
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, People's Republic of China.
概括
血红蛋白,白蛋白,淋巴细胞计数和血小板计数 (HALP) 的得分在糖尿病视网膜病变 (DR) 患者中较低. 监测HALP得分可以帮助早期的DR查,特别是对于男性2型糖尿病患者.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 糖尿病视网膜病变 (DR) 是2型糖尿病 (T2DM) 患者视力丧失的主要原因.
- 早期检测和风险分层对于管理DR和预防视力障碍至关重要.
研究的目的:
- 为了研究血红蛋白,白蛋白,淋巴细胞计数,血小板计数 (HALP) 评分和T2DM患者中DR的存在之间的关联.
- 评估HALP得分作为DR风险和诊断的潜在生物标志物.
主要方法:
- 一项涉及674名T2DM患者的横截面研究,根据 fundus检查将其分为非糖尿病视网膜病变 (NDR) 和DR组.
- 收集基线数据,计算HALP得分,并进行统计分析,以确定HALP得分与DR之间的相关性.
- 开发和评估一个综合诊断模型,包括HALP得分,疾病持续时间,缩血压 (SBP) 和血尿素 (BUN).
主要成果:
- 与NDR组相比,DR组的患者表现出明显较低的HALP得分,无论男女 (P<0.001).
- HALP得分与DR发病率负相关 (P<0.05) 并被确定为DR的独立风险因素.
- 综合诊断模型显示了DR的高诊断准确性,特别是在男性患者中 (AUC=0.761).
结论:
- 哈尔普得分是DR的独立风险因素,需要监测,特别是在男性T2DM患者中.
- 结合HALP得分,疾病持续时间,SBP和BUN的综合诊断模型显示为早期DR查的工具.
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