可生物降解的表面的耐腐蚀性,通过紫外线接种的聚二甲基氧涂层增强
Davide Pupillo1, Mark P Bruns2, Lucia H Prado2
1Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy.
ACS biomaterials science & engineering
|July 15, 2024
概括
可生物降解的支架在表面修改后表现出更好的耐腐蚀性,使用酸和油 (PDMS). 这种疏水性涂层可以减少腐蚀和细胞毒性,增强它们在血管应用中的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 心血管工程 心血管工程
背景情况:
- 预期寿命的增加导致血管疾病的发病率更高.
- 可生物降解的血管支架提供临时支持,但面临着腐蚀和炎症反应的挑战.
- 控制的降解对于可生物降解金属植入物的有效性至关重要.
研究的目的:
- 为了提高可生物降解 (Zn) 表面的耐腐蚀性,用于血管支架应用.
- 为了研究用酸和聚甲基 (PDMS) 表面修饰对模拟体液中腐蚀的影响.
- 评估修改表面对细胞毒性和离子释放的影响.
主要方法:
- 在 Zn 表面上无电流沉积氧化酸.
- 聚甲西洛 (PDMS) 的紫外线移植到酸酸层上.
- 潜在动力学极化和电化学阻抗光谱学.
- 呼吸机动力学测量和长期沉浸试验在模拟的体液中.
主要成果:
- 基酸部分改善了 Zn 的耐腐蚀性.
- 紫外线将PDMS移植到酸上,形成了一个疏水的表面.
- 在生物环境中,PDMS涂层使基材料腐蚀减少了三倍.
- 修改后的表面通过控制Zn离子的释放来降低细胞毒性.
结论:
- 用基酸盐和疏水性PDMS进行表面修改,显著提高了可生物降解 Zn. 的耐腐蚀性.
- 这种方法提供了一个有前途的策略,以提高可生物降解血管支架的性能和安全性.
- 控制腐蚀和减少离子释放是临床转化的主要好处.
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