基于Pt-Te-Nanorod的光热化学基因免疫疗法用于通过适应性和先天免疫来治疗所有癌症阶段
Seounghun Kang1, Yeong-Gyu Gil2, Se-Youl Chae1
1Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea.
ACS applied materials & interfaces
|July 15, 2024
概括
这项研究引入了Pt-Te纳米棒 (PtTeNRs) 来稳定化学因子 (C-X-C) 动机连接体9 (CXCL9) 以加强癌症免疫疗法. 新的PtTeNR-CXCL9系统,结合光热疗法和抗PD-1抗体,在所有癌症阶段都显示出显著的瘤抑制.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 免疫治疗是一种免疫疗法.
背景情况:
- 化基因 (C-X-C) 基因连接体9 (CXCL9) 在招募效应性T细胞和自然杀手细胞用于癌症免疫治疗方面表现有前途.
- 由于免疫毒性和体内稳定性差,CXCL9的实际应用受到阻碍.
- 开发稳定有效的CXCL9输送系统对于其治疗潜力至关重要.
研究的目的:
- 设计和合成 Telluride 纳米棒 (PtTeNRs) 作为CXCL9.9的稳定输送载体.
- 为了研究结合PtTeNR载CXCL9,光热 (PT) 疗法和抗编程细胞死亡蛋白1 (aPD-1) 抗体用于癌症治疗的三模式疗法的疗效.
- 评估这种联合治疗对瘤抑制的协同效应.
主要方法:
- 具有稳定的CXCL9有效载荷特征的PtTeNRs的合成.
- 在瘤组织中PtTeNR载CXCL9的体内积累和持续释放.
- 组合疗法涉及PtTeNR-CXCL9,PT疗法和aPD-1抗体的使用.
- 对效应T细胞招募和瘤抑制功效的评估.
主要成果:
- PtTeNRs表现出极好的光热转换效率和稳定的CXCL9有效载荷.
- 带有PtTeNR的CXCL9被有效地传递和释放到瘤中,招募效应T细胞.
- 在三模治疗 (PtTeNR-CXCL9 + PT + aPD-1) 中观察到显著的协同瘤抑制效应.
- 组合疗法在所有癌症阶段 (1-4) 和复发性瘤中表现出卓越的疗效.
结论:
- PtTeNRs为癌症免疫治疗中CXCL9的输送提供了一个稳定有效的平台.
- 结合PtTeNR-CXCL9,PT和aPD-1抗体的三模式治疗为全面的瘤抑制提供了一个强有力的策略.
- 这种方法对治疗癌症的各个阶段,包括复发,具有显著的前景.
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