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药物使用障碍作为血管中输管风险因素:全国性队列研究

Joseph Bogart^1,2, Todd Otteson^1,2

¹Case Western Reserve University School of Medicine, Cleveland, Ohio, U.S.A.

The Laryngoscope

|July 15, 2024

概括

患有物质使用障碍 (SUD) 的患者面临严重血管 (AE) 和呼吸道并发症的风险增加,包括输管. 这凸显了SUD作为AE气道管理的关键因素.

科学领域:

医学研究医学研究
肺部病理学肺部病理学
紧急医疗紧急医疗

背景情况:

血管 (AE) 具有严重的呼吸道损害风险,往往需要内管道输入管道.
导致AE患者出现呼吸道损伤的因素尚未确定.
药物使用障碍 (SUD) 是AE患者呼吸道损害的潜在,但尚未研究的风险因素.

研究的目的:

调查物质使用障碍 (SUD) 与患有血管 (AE) 的患者需要呼吸道干预之间的关联.
确定患者特异性因素,特别是SUD,预测AE病例中严重的气道损害.

主要方法:

一个基于人口的回顾性队列研究,利用TrinetX国家数据库.
与SUD的AE患者与没有SUD的倾向匹配的对照组的AE患者的比较.
包括28931名SUD患者和117,509名没有SUD患者的AE患者,分析住院,输管和气管切割率.

主要成果:

所有SUD亚型 (酒精,大麻,可卡因,烟草,阿片类药物) 与非SUD队列相比,与严重AE的风险更高有关.
患有SUD的AE患者的住院率从20.4% (烟草使用障碍) 到30.4% (可卡因使用障碍),明显高于非SUD组的8.0%.
每个SUD亚型都显示了输管率的增加,大麻使用障碍具有最高的相对风险 (RR=3.67). 烟草和酒精使用障碍与更高的气管切割风险有关.

结论:

患有SUD的患者,无论亚型如何,在呈现AE时,表现出增加不良结果的风险,包括气道损害.
SUD被确定为在血管中呼吸道损害的临床显著预测因素.
这些发现强调了在AE患者的管理中考虑SUD的重要性,以预测和减轻气道并发症.

关键词:

血管内血管内输入管道是输入管道.国家数据库国家数据库.药物使用障碍物使用障碍物.

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