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Updated: Jun 21, 2025

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TET3有助于运动诱导的功能性轴突再生和视觉恢复

Si Fang1, Yunxiang Ji1, Yilan Shen2

  • 1Multiscale Research Institute of Complex Systems, Department of Integrative Oncology in Fudan University Shanghai Cancer Center, Jingan District Central Hospital of Shanghai, Department of Otorhinolaryngology-Head and Neck Surgery in Huashan Hospital, Fudan University, Shanghai, 200433, China.

Advanced biology
|July 15, 2024
PubMed
概括

运动通过重新编程表观遗传模式来增强中枢神经系统 (CNS) 中的轴突再生. 这促进视力恢复,并涉及TET3介导的基因表达,提供新的治疗点.

关键词:
在TET3的基础上.老化的老化 衰老的老化这是表观遗传重编程.运动就是炼身体.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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