习惯性咖啡因使用与两个样本中对实验室压力的皮质醇反应性增加有关
Elli L Cole1, Alessandra R Grillo, Suzanne Vrshek-Schallhorn
1From the Department of Psychology. University of North Carolina at Greensboro, Greensboro, North Carolina.
Psychosomatic medicine
|July 15, 2024
概括
习惯性咖啡因消费会增加皮质醇对压力的反应性,可能掩盖抑郁症风险因素. 这表明咖啡因可以通过压力反应调节来保护抑郁症.
科学领域:
- 心理神经内分泌学心理学
- 压力和健康 压力和健康
- 行为科学 行为科学
背景情况:
- 习惯性咖啡因摄入与通过未知的机制保护抑郁症有关.
- 咖啡因对皮质醇对心理社会压力的反应的影响还没有得到充分研究.
- 咖啡因可能会减轻患抑郁症风险的个体的压力诱导的皮质醇变化.
研究的目的:
- 调查是否习惯性和急性咖啡因使用预测皮质醇对实验室心理社会压力的反应性.
- 为了确定咖啡因的使用是否掩盖了特征反对压力反应中皮质醇反应的冲击.
主要方法:
- 两个独立的新兴成年人样本 (N=128,N=148) 接受了基于实验室的心理社会压力测试 (Trier社会压力测试).
- 参与者接受了对照,模两可的评价或负面的评价条件.
- 多级增长曲线建模分析了习惯性和急性咖啡因使用,压力状态和皮质醇反应性,考虑了特征反.
主要成果:
- 习惯性咖啡因使用,而不是急性使用,在两个样本中预测了皮质醇对压力的高反应性.
- 在一个样本中,与反相关的皮质醇反应的减弱仅在非咖啡因使用者中观察到,与使用者有显著差异.
- 在第二个样本中,无论咖啡因消耗量如何,都观察到这种变的模式.
结论:
- 习惯性咖啡因消费与心理社会压力期间皮质醇释放增加有关.
- 咖啡因可能会掩盖心理社会因素 (如反) 对压力诱导的皮质醇反应的影响.
- 未来的研究应该探索咖啡因诱导的皮质醇释放在抑郁症预防中的行为激活效应.
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