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在黑人和白人患有炎症性肠病的患者中治疗粘膜

Devika Dixit¹, Nicole C Ruiz², Steve Shen¹

¹Department of Medicine, Division of Internal Medicine, University of Florida, Gainesville, Florida, USA.

Clinical and translational gastroenterology

|July 15, 2024

概括

患有炎症性肠病 (IBD) 的黑人患者表现出比白人患者更高的粘膜愈合 (MH) 率的趋势,尽管治疗方法相似. 这表明,MH可能不仅仅是IBD结果差异的解释.

科学领域:

胃肠病学胃肠病学
临床医学临床医学
健康差异在健康上的差异

背景情况:

炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,涉及慢性胃肠道炎症.
粘膜愈合 (MH) 是IBD患者的一个关键治疗目标.
现有的数据表明,黑人和白人的IBD临床结果可能存在差异.

研究的目的:

为了研究和比较黑人与白人患者的粘膜愈合 (MH) 率,这些患者被诊断患有炎症性肠病 (IBD).

主要方法:

对因IBD爆发而住院的成年黑白患者进行了回顾性分析.
粘膜愈合 (MH) 被评估为住院后6-18个月.
记录和分析了住院前后的治疗数据和C-反应蛋白 (CRP) 水平.

主要成果:

该研究包括109名患者:88名白人 (80.7%) 和21名黑人 (19.3%).
在整个研究期间,两组都接受了可比的IBD治疗.
与白人患者 (60.2%) 相比,黑人患者在数值上表现出更高的MH率 (71.4%),尽管在统计学上不显著 (P=0.3).

结论:

在接受类似护理的住院IBD患者中,与白人患者相比,在黑人患者中观察到更大的粘膜愈合的趋势.
这些发现表明,除了粘膜愈合之外的因素可能会导致黑人和白人的IBD患者在临床结果中观察到的差异.

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