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用基于Se的核心卫星纳米组件重新编程瘤相关的巨细胞,以增强癌症免疫疗法

Xia Zhang¹, Guocheng Li¹, Jiaqi Yin¹

¹College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.

|July 15, 2024

概括

这项研究引入了一种新的Se@ZIF-8纳米组件,该组件可以将瘤相关的巨细胞 (TAM) 从M2重编程到M1类型. 这种重编程通过逆转免疫抑制瘤微环境来增强癌症免疫疗法.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

瘤相关巨细胞 (TAMs) 是瘤微环境中的关键免疫细胞,经常促进瘤的进展.
将TAM从免疫抑制M2表型重新编程为抗瘤M1表型是癌症免疫治疗的一个有前途的策略.

研究的目的:

设计一个Se@ZIF-8核心卫星纳米组件,以便有效地进行TAM重编程.
研究这种纳米组件在增强癌症免疫治疗结果方面的潜力.

主要方法:

制造Se@ZIF-8核心卫星纳米组件.
评估纳米组件对酸性瘤微环境的反应.
对活性氧物种 (ROS) 生产和NF-κB通路激活的评估.
从M2到M1表型的TAM再极化分析.
癌细胞死亡诱导和巨细胞灭菌的研究.

主要成果:

在酸性条件下,Se@ZIF-8纳米组件释放纳米粒子和Zn2+,促进ROS的产生.
升高的ROS水平激活NF-κB通路,导致TAM重偏向到M1表型.
该纳米组件诱导癌细胞免疫性死亡,并增强巨细胞化.
设计的纳米组件有效地逆转了免疫抑制瘤微环境.

结论:

Se@ZIF-8核心卫星纳米组件显示了重编程TAM和增强癌症免疫治疗的巨大潜力.
这种方法为克服免疫抑制瘤微环境并提高治疗效率提供了一种新的策略.

关键词:

癌症癌症癌症癌症癌症核心 - 卫星纳米组件组件免疫疗法免疫疗法有活性氧物种的反应性氧物种.与瘤相关的巨细胞.

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