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Updated: Jun 21, 2025

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固体瘤的微环境:芯片上的瘤模型的组件和当前挑战

Ilva de Fátima Souza1, João Paulo de Jesus Vieira1,2, Elton Diêgo Bonifácio1

  • 1Institute of Science and Technology, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, Brazil.

Tissue engineering. Part B, Reviews
|July 15, 2024
PubMed
概括

先进的瘤芯片模型为瘤微环境 (TME) 和癌细胞相互作用提供了新的见解. 这些体外工具有助于开发更有效的癌症治疗方法,尽管广泛的研究应用仍然存在局限性.

关键词:
在芯片上的癌症.微流体设备的微流体设备固体瘤是一种固体瘤.瘤微环境是一个微环境.

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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