在哺乳小鼠中,母乳衍生的抗体会降低疫苗免疫力
Tanushree Dangi1, Sarah Sanchez1, Bakare Awakoaiye1
1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Journal of immunology (Baltimore, Md. : 1950)
|July 15, 2024
概括
母乳抗体 (Abs) 可以保护婴儿,但可能会阻碍疫苗反应. 接种疫苗的母亲的母乳养通过加速抗原清除来降低新生儿的免疫力,影响血细胞的发育.
科学领域:
- 免疫学 免疫学 免疫学
- 新生儿健康 新生儿健康
- 疫苗学 疫苗学 疫苗学
背景情况:
- 母乳通过抗体 (Abs) 为新生儿提供了被动免疫力.
- 母乳中的母体抗体对婴儿疫苗反应的影响尚不清楚.
- 了解这种相互作用对于优化新生儿疫苗接种策略至关重要.
研究的目的:
- 为了研究是否从接种疫苗的母乳养会影响新生小鼠的疫苗诱导免疫力.
- 确定母体抗体可能影响新生儿对疫苗免疫反应的机制.
主要方法:
- 使用了C57BL/6和BALB/c小鼠模型.
- 采用了一种实验系统,通过全型区分母亲和新生儿抗体.
- 使用mRNA-luciferase记者系统来跟踪抗原 (Ag) 清除.
主要成果:
- 从mRNA-SARS-CoV-2-接种疫苗的母乳养与新生小鼠的疫苗免疫力降低有关.
- 免疫母婴的新生儿在接种疫苗后的血细胞数量较少,相比于幼稚母婴的新生儿.
- 母亲抗体加速了哺乳小鼠的疫苗抗原清除,减少了抗原的可用性.
结论:
- 通过母乳传递的母体抗体,虽然对病原体有保护作用,但可能会损害新生儿的疫苗反应.
- 通过母体抗体加速清除疫苗抗原,降低新生儿发展自身免疫力的能力.
- 这些发现为提高新生儿疫苗的疗效提供了洞察力.
相关概念视频
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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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