对母亲的希望:在异性造血细胞移植后怀孕 (全国多中心研究)
Katja Sockel1, Annika Neu2, Maren Goeckenjan3
1Department of Internal Medicine I, University Hospital Dresden, Technical University Dresden, Dresden, Germany.
Blood
|July 15, 2024
概括
接受异性造血细胞移植 (alloHCT) 的年轻成年癌症幸存者有很大的怀孕机会. 虽然出生率低于一般人口,但发生自发怀孕,突出了需要生育咨询的需要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 生殖医学 生殖医学
背景情况:
- 在异性造血细胞移植 (alloHCT) 后改善生存率,需要针对年轻成年幸存者的计划生育.
- 与治疗相关的不孕症是影响alloHCT后生殖选择的一个重大挑战.
研究的目的:
- 根据alloHCT,评估当代成年女性的怀孕和出生率.
- 为了确定与妊娠后的相关因素alloHCT.
- 为所有HCT幸存者的生育咨询提供信息.
主要方法:
- 一项使用德国移植注册表的国家多中心研究.
- 分析了2003年至2018年间接受alloHCT的成年女性 (18-40岁) 的数据.
- 怀孕结果的评估,包括活产率和影响因素.
主要成果:
- 在2654名女性中,50名女性经历了74次怀孕 (77%的活产),移植后的中位数为4.7年.
- 活产的10年概率为3.4%,年初出生率为0.45%.
- 怀孕的可能性随着年龄的年轻,非恶性征兆,较低的辐射剂量和降低强度的调节而增加.
结论:
- 成年女性alloHCT接受者有很大的怀孕机会,许多怀孕是自发的.
- 辅助生殖技术很重要,但不应低估自发怀孕.
- 需要进一步研究条件对生育保护和咨询需求的影响.
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