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结合SARS-CoV-2非结构蛋白 1至40S 核糖体抑制mRNA翻译

Hung Nguyen1, Hoang Linh Nguyen2,3, Mai Suan Li1,4

  • 1Institute of Physics, Polish Academy of Sciences, al. Lotnikow 32/46, 02-668 Warsaw, Poland.

The journal of physical chemistry. B
|July 15, 2024
PubMed
概括

SARS-CoV-2 NSP1增强了mRNA与40S核糖体的结合,抑制了翻译. 分子动力学模拟揭示了静电相互作用,水分子是这个过程的关键,精确地确定了参与翻译停止的NSP1残留物.

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