美国青少年中的肝移植概况
Saleh A Alqahtani1, Maria Stepanova2, Dipam Shah3
1The Global NASH Council, Washington, D.C.; Organ Transplant Center of Excellence, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; Division of Gastroenterology & Hepatology, Johns Hopkins University, Baltimore, Maryland.
概括
与成年人相比,青少年的肝移植 (LT) 显示出独特的指示. 结果正在改善,青少年接受LT的3年生存率达到90%.
科学领域:
- 肝病学和移植外科手术
- 儿科胃肠病学 儿科胃肠病学
背景情况:
- 肝移植 (LT) 指示在儿童和成人群体之间存在显著差异.
- 了解影响青少年LT结果的特定因素对于改善患者护理至关重要.
研究的目的:
- 确定美国青少年肝移植 (LT) 候选人和接受者的预测结果.
- 分析青少年LT等候名单患者的社会人口统计和临床特征.
主要方法:
- 利用了2008-2022年移植受体科学注册表 (SRTR) 的数据.
- 分析了2,813名青少年 (13-19岁) LT候选人的临床,社会和人口统计数据.
- 年轻 (13-16岁) 和年长 (17-19) 青少年年龄组之间的比较特征.
主要成果:
- 急性肝病是青少年最常见的LT征兆 (23.5%),与成年人不同.
- 67.2%的候选人接受了移植,移植率随着时间的推移而有所改善.
- 接受移植的预测因素包括最近一年,年龄较小,MELD得分较高和急性肝病.
- 三年生存率为90%,趋势有所改善;与较高死亡率相关的因素包括年龄,医疗补助和肝细胞癌.
结论:
- 青少年LT的征兆与成人和幼儿的征兆不同.
- 青少年的移植后生存率正在改善,突出显示了护理方面的进步.
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