关节和个体线粒体DNA变异以及黑人和白人老年人的认知结果
Michelle C Odden1, Yongmei Li1, Vasantha Jotwani2,3
1Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford, California, USA.
概括
复合I的线粒体DNA (mtDNA) 变异与老年人的认知功能有关. 特定的变体在不同种族群体中不同影响认知衰退,突出了与年龄相关的认知变化中的潜在遗传因素.
科学领域:
- 遗传学 遗传学 是一个
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 线粒体功能障碍与神经退行性和与年龄相关的疾病有关.
- 遗传的线粒体DNA (mtDNA) 变异可能会影响认知衰老.
研究的目的:
- 为了研究mtDNA序列变异与黑人和白人老年人的认知功能之间的关联.
- 为了识别与认知表现和随时间的下降相关的特定mtDNA变异.
主要方法:
- 来自LIFE和Health ABC衰老研究的2,107名黑人和白人参与者 (≥70岁) 的mtDNA序列分析.
- 使用数字符号替换测试 (DSST) 和修改型迷你精神状态检查 (3MSE) 评估认知功能.
- 用序列内核关联测试和混合效应模型元分析来检查变体与认知措施的关联.
主要成果:
- 与认知功能 (DSST,3MSE) 相关的复合I子单元 (ND1,ND2,ND5),12SRNA和超变区 (HVR) 的联合变化.
- 在黑人参与者中,m.4216T>C (ND1) 与更快的3MSE衰退相关;m.462C>T (HVR) 与更慢的DSST衰退相关.
- 在白人参与者中,m.5460G>C (ND2) 与3MSE衰退速度较慢相关;m.182C>T (HVR) 与3MSE衰退速度较快相关.
结论:
- 氧化酸化复合I变体显示出与老年黑人和白人成年人的认知功能有显著的关联.
- 特定的mtDNA变异可能会根据种族对认知轨迹产生不同的影响.
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