初级免疫缺陷患者的胃肠道系统参与:一个单一中心的经验
Tugba Guler1, Ilknur Kulhas Celik1, Anna Carina Ergani2
1Selcuk University Medical Faculty, Pediatric Immunology and Allergy, Konya, Turkey.
Scandinavian journal of gastroenterology
|July 15, 2024
概括
营养不良和腹等胃肠道症状在一次性免疫缺陷 (PID) 中很常见. 识别这些迹象有助于早期诊断和治疗儿童PID.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
背景情况:
- 初级免疫缺陷 (PID) 是一组多样化的疾病,其特点是免疫系统受损,对感染的易感性增加和各种临床问题,包括胃肠道 (GI) 并发症.
- 早期识别PID对于有效管理和改善患者的治疗结果至关重要.
研究的目的:
- 评估小儿PID患者的胃肠道表现的范围.
- 强调非典型的胃肠道症状在PID早期诊断中的作用.
主要方法:
- 在2011年至2021年期间诊断出PID的101名儿科患者的回顾性分析.
- 包括人口统计数据,临床表现,遗传突变和胃肠道表现,并进行内镜评估.
- 基于国际免疫学会联盟 (IUIS) 的PID分类和PID类型和GI表现物的统计分析,对患者进行分类.
主要成果:
- 46%的患者表现出胃肠道症状,营养不良和慢性腹是最常见的.
- 主要抗体缺乏症 (PAD) 是最常见的与胃肠道问题相关的PID,其次是联合免疫缺陷症 (CID).
- 内镜检查结果包括IBD类结肠炎在一个显著的子组,以及与某些PID类别相关的特定GI症状.
结论:
- 在儿科PID患者中识别常见的GI症状可以导致更早的诊断和多学科护理.
- 在诊断儿童持续或严重的胃肠道症状时,考虑PID至关重要.
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