骨髓微环境对血液恶性瘤中CAR-T疗效的作用
Dandan Gao1, Fei Hong1, Aili He1,2
1Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Scandinavian journal of immunology
|July 15, 2024
概括
化学抗原受体-T (CAR-T) 细胞疗法在治疗血液癌症方面表现有前途. 本综述探讨了骨髓微环境如何影响CAR-T疗效,并提出了改善治疗结果的策略.
科学领域:
- 免疫治疗是一种免疫疗法.
- 在瘤学瘤学.
- 细胞疗法 细胞疗法
背景情况:
- 化学抗原受体-T (CAR-T) 细胞疗法是一种新型免疫疗法,在治疗血液性B细胞恶性瘤方面具有显著的疗效.
- 针对CD19的CAR-T疗法在急性B淋巴细胞白血病 (B-ALL) 和非霍奇金淋巴瘤 (NHL) 中显示出了显著的结果.
- 血液性恶性瘤中的瘤干细胞通常存在于保护性骨髓微环境中,逃避免疫攻击.
研究的目的:
- 审查骨髓微环境对血液恶性瘤中CAR-T细胞疗法的疗效的影响.
- 阐明骨髓微环境影响抗瘤活性的机制.
- 提出提高骨髓利基内CAR-T细胞疗法有效性的策略.
主要方法:
- 关于CAR-T细胞治疗和骨髓微环境的现有研究的文献综述.
- 分析了骨髓利基中免疫逃避背后的机制.
- 综合当前的知识,以确定潜在的治疗策略.
主要成果:
- 骨髓微环境对CAR-T细胞的疗效提出了独特的挑战,原因是瘤干细胞的保护.
- 骨髓内的特定因素可能会损害CAR-T细胞的功能和持续性.
- 了解这些相互作用对于克服治疗耐药性至关重要.
结论:
- 骨髓微环境对血液癌症中CAR-T细胞疗法的有效性有显著影响.
- 准或调节骨髓微环境可能是提高CAR-T细胞治疗结果的关键策略.
- 需要进一步的研究来开发和验证克服骨髓介导抗性的新方法.
相关概念视频
01:22Bone Marrow Sampling and Transplants
323
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
323
01:28Role of Hematopoietic Growth Factors
1.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.3K
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:21Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:19Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K