CD147 TagSNP与中国人群患肺癌的脆弱性有关:一个病例对照研究
Yuning Xie1,2, Chu Huang3, Xianlei Zhou1
1School of Public Health, North China University of Science and Technology, 21 Bohai Road, Caofeidian Xincheng, Tangshan, 063210, Hebei, China.
Discover oncology
|July 15, 2024
概括
特定的CD147基因变异在某些汉族人群中增加肺癌风险,特别是在女性和老年人中. 这些遗传因素与人口统计数据相结合,对于了解肺癌的发展至关重要.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 由于高发病率和死亡率,肺癌仍然是全球健康负担之一.
- CD147与癌症的进展和转移有关,使其成为潜在的治疗点.
- CD147中的遗传变异可能会影响肺癌风险.
研究的目的:
- 调查CD147单核酸多态 (SNPs) 与肺癌风险之间的关联.
- 分析汉族中国人群中的这些关联.
主要方法:
- 一项基于医院的病例控制研究,涉及700名肺癌患者和700名对照.
- 在CD147基因中使用Haploview和1000基因组数据选择TagSNP (rs28992491,rs67945626,rs79361899).
- 用改进的多重结检测反应方法进行基因型鉴定,并进行统计分析,包括千平方测试和后勤回归.
主要成果:
- 研究的CD147SNP与肺癌易感性之间没有总体关联.
- 分层分析显示,女性的rs79361899基因型 (AA/AG) 风险增加.
- 在65岁及以上的个体中观察到rs28992491 (GG) 和rs79361899 (AA) 基因型的敏感性增加.
- 对rs79361899的显著基因型×性别相互作用,表明具有特定基因型的女性的风险更高.
结论:
- CD147多态性在肺癌病因学中很重要,特别是在特定的年龄和性别子组中.
- CD147中的遗传变异与人口因素相互作用,影响肺癌风险.
- 这些发现有助于更深入地了解肺癌复杂的起源.
相关概念视频
Single Nucleotide Polymorphisms-SNPs
15.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.0K
lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Genome-wide Association Studies-GWAS
13.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.3K


