关于上皮卵巢癌的SEOM-GEICO临床指南 (2023)
Jose Alejandro Perez-Fidalgo1, Fernando Gálvez-Montosa2, Eva María Guerra3
1Hospital Clínico Universitario, Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain. japfidalgo@msn.com.
概括
新的治疗策略和生物标志物改善了上皮卵巢癌 (EOC) 的结果,但耐药性仍然是一个挑战. 本指南为管理EOC提供基于证据的建议,帮助临床医生进行诊断和治疗.
科学领域:
- 在瘤学瘤学.
- 妇科瘤学 妇科瘤学
- 翻译癌症研究 翻译癌症研究
背景情况:
- 表皮卵巢癌 (EOC) 管理已经发展出新的治疗策略.
- 生物标志物发现有助于选择患者接受向治疗.
- 尽管取得了进展,但EOC仍然是一个致命的疾病,常常具有耐治疗性.
研究的目的:
- 巩固目前管理上皮卵巢癌的策略.
- 帮助临床医生在复杂的诊断和治疗途径上进行导航.
- 为EOC患者护理提供基于证据的建议.
主要方法:
- 对EOC近期治疗进展的系统审查.
- 预测和预后生物标志物的实用性的分析.
- 为制定临床指导方针进行证据综合.
主要成果:
- 新药的加入改变了EOC患者的治疗结果.
- 生物标志物促进了个性化治疗选择.
- 由于共同的抵抗机制,挑战仍然存在.
结论:
- 目前的管理策略为EOC提供了改善的,但不是最终的结果.
- 对抗性机制的持续研究至关重要.
- 本指南为最佳的EOC临床管理提供了一个框架.
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