骨髓原抑制细胞在各种疾病中的双重作用:一篇综述
Mahesh Raj Nepal1,2,3, Sajita Shah1,2,4, Kyu-Tae Kang5,6
1College of Pharmacy, Duksung Women's University, Seoul, South Korea.
Archives of pharmacal research
|July 15, 2024
概括
骨髓衍生抑制细胞 (MDSCs) 有双重作用. 它们可以防止自身免疫性疾病和过敏,但通过抑制免疫系统,会使感染和癌症恶化.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 骨髓衍生抑制细胞 (MDSCs) 是一种来自骨髓干细胞的异质细胞群.
- 病理状况,如自身免疫性疾病,过敏,感染和癌症改变正常的骨髓形成,导致MDSC的形成.
- 最初被认为通过免疫抑制促进癌症,最近的研究强调了它们复杂的作用.
研究的目的:
- 综合审查MDSC与各种病理疾病之间的关联.
- 阐明MDSC在不同生理和病理环境中的双重作用.
- 简要描述针对MDSCs的治疗方法.
主要方法:
- 文献综述和对MDSCs现有研究的综合.
- 对研究MDSC功能在各种疾病中的研究进行分析.
- 关于MDSC介导的免疫抑制机制的信息汇编.
主要成果:
- 在自身免疫性疾病 (例如,紫外线炎,多发性硬化症,1型糖尿病,狼),过敏和器官移植中,MDSCs起着保护作用.
- 相反,MDSCs通过促进免疫抑制,在感染和各种癌症中表现出有害影响.
- 在不同疾病状态中,已经确定了MDSCs的特定免疫抑制功能和机制.
结论:
- MDSC具有取决于环境的功能,在某些条件下起保护作用,在其他条件下起损害作用.
- 了解MDSCs的双重作用对于开发有针对性的治疗策略至关重要.
- 对MDSC机制的进一步研究可能会导致一系列疾病的新疗法.
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