核因子-Kappa B和抑制剂-Kappa B参数之间的关系与COVID-19患者的临床过程
Melek Karasu1, Muhdi Cevik2, Serap Biberoglu2
1Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey. melekkarasu@hotmail.com.
血清核因子卡帕B (NF-κB) p105水平在轻度/中度COVID-19患者中升高,可能有助于预测需要氧气. 这一发现为疾病过程提供了诊断和预后价值.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 在2019年冠状病毒病 (COVID-19) 中调查炎症标志物对于理解疾病的发病过程至关重要.
- 核因子卡帕B (NF-κB) 信号通路与炎症反应有关.
- 特定的NF-κB通路组件,如p105,p65和抑制剂卡帕Bαα (IκBα) 在COVID-19中需要检查.
研究的目的:
- 在患有轻度/中度COVID-19的患者中确定NF-κB p105,NF-κB p65和IκBα的血清水平.
- 评估这些标记物与COVID-19的临床过程和严重程度的关联.
- 评估NF-κB p105在COVID-19早期阶段的诊断和预后潜力.
主要方法:
- 血清样本从35名轻度/中度COVID-19患者和35名健康对照在诊断时收集.
- 使用国家早期预警分数2 (NEWS2) 和CT发现来评估疾病的严重程度.
- 酶相关免疫试验 (ELISA) 用于测量NF-κB p105,NF-κB p65和IκBα水平;进行受体操作特征 (ROC) 分析.
主要成果:
- 与对照组相比,在COVID-19患者中观察到血清NF-κB p105水平显著更高.
- 在COVID-19患者中,C-反应蛋白 (CRP),D-二聚体和费里丁的含量增加,淋巴细胞数量较低.
- 在需要补充氧气的患者中,NF-κB p105水平显著更高,这表明与疾病严重程度的联系.
结论:
- 在早期感染阶段血清NF-κB p105升高表明COVID-19的诊断效用.
- NF-κB p105可以作为预后标记,预测在住院期间需要补充氧气的需要.
- 对NF-κB通路调节的进一步研究可能为COVID-19提供治疗点.
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