管理Clostridioides困难感染:一个意大利的德尔菲共识共识
Matteo Bassetti1, Antonio Cascio2, Francesco Giuseppe De Rosa3
1Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
The Journal of antimicrobial chemotherapy
|July 15, 2024
概括
通过专家的共识,Clostridioides difficile感染 (CDI) 管理指南进行了更新. 菲达克索米辛在预防CDI复发和保护肠道微生物群方面具有优势,尽管成本障碍很大.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 艰难结肠杆菌感染 (CDI) 是医院获得的死亡的主要原因,与肠道微生物群的破坏有关.
- 广泛的抗生素,如万科米辛和甲尼达可以增加CDI复发的风险.
- 菲达克索米辛是一种窄谱抗生素,在预防CDI复发和保护微生物群方面表现有前途,但面临成本挑战.
研究的目的:
- 巩固现有的Clostridioides difficile感染管理指南.
- 为了确定fidaxomicin在CDI治疗中使用的最佳时间.
主要方法:
- 专家小组召开会议,通过使用Delphi方法论就CDI管理声明达成共识.
- 声明的重点是CDI管理和适当的抗生素选择.
主要成果:
- 在25个关于CDI管理的陈述中,就21个达成共识.
- 达成协议,确定高风险患者和适当的fidaxomicin利用.
结论:
- 德尔菲方法促进了关于CDI管理,风险分层和最佳fidaxomicin使用的共识.
- 这种共识可以指导临床实践,促进具有成本效益的CDI治疗,特别是在资源有限的环境中.
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