与丹麦普通人口相比,阻塞性泌尿病患者的癌症风险和预后
Mette Nørgaard1,2, Dóra Körmendiné Farkas1,2, Madeleine A Gotschalck3
1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
概括
阻塞性泌尿病与更高的癌症风险有关,特别是泌尿,妇科和结直肠癌. 在阻塞性尿路病变后被诊断患有癌症的患者也面临较高的死亡率.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 阻塞性泌尿病可能表明患癌症的风险增加.
- 了解这种关联对于患者管理和早期癌症检测至关重要.
研究的目的:
- 调查阻塞性泌尿病与癌症风险之间的关联.
- 为了比较癌症患者与没有先前阻塞性尿路病的死亡率.
主要方法:
- 一项全国性的丹麦队列研究分析了37,275名被诊断患有阻塞性尿路病的成年患者.
- 评估了癌症发生率和标准化发生率比率 (SIR).
- 癌症患者与没有阻塞性尿路病变之间的死亡率进行了比较,关键因素相匹配.
主要成果:
- 在被诊断为阻塞性泌尿病后,观察到3个月癌症风险为9.6%,初始SIR高 (34.2).
- 在短期内,尿道 (82.7),妇科 (88.8) 和结肠直肠 (13.9) 癌症的SIR值升高.
- 在癌症患者中,与没有 (53.2%) 相比,先前有阻塞性尿路病变的癌症患者的五年全因死亡率更高 (64.1%).
结论:
- 第一次阻塞性尿路病的诊断可以作为未被诊断的癌症的临床标志物.
- 死亡率升高与在阻塞性尿路病变后诊断的癌症有关.
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