在正常或不正常的精子中进行一线不孕症治疗:对简化IMSI前测试的兴趣
Julien Sigala1, Sophie Poirey1, Julien Robert2
1Department of Reproductive Biology, Nîmes University Hospital, Nîmes, France.
PloS one
|July 15, 2024
概括
简化的IMSI前测试 (PIT) 有助于选择男性不孕症的最佳辅助生殖技术 (ART). 这项测试指导了IVF,IUI,ICSI和IMSI之间的选择,以改善精选夫妇的怀孕结果.
科学领域:
- 生殖医学与神经病理学
- 精子形态分析分析精子形态分析.
- 辅助生殖技术 (ART) 是一种辅助生殖技术.
背景情况:
- 基本的精液检查可以通过对男性不孕症的附加测试来加强.
- 精子正常/不正常的选择不育患者可能会从先进的诊断中受益.
- 以前的ART失败 (IUI,IVF,ICSI) 需要精细的诊断方法.
研究的目的:
- 开发和验证一种更快,更简单的运动精子器官形态检查 (MSOME) 技术.
- 评估IMSI前测试 (PIT) 对于正常/不正常精子的选择不育患者.
- 为了将PIT分数与IUI,试管婴儿,ICSI和IMSI的结果相关联.
主要方法:
- 一种适应的MSOME技术,即IMSI前测试 (PIT),通过真空评估进行了验证.
- 248名不育患者被追溯分为三个PIT分数子组 (I,II,III).
- 选择ART技术是基于每个患者的标准临床生物学标准.
主要成果:
- 皮特评分显著影响了ICSI临床怀孕 (p=0.0054) 并显示出活产的趋势 (p=0.0614).
- 在试管婴儿试验中流产率根据PIT得分 (p=0.0348) 有显著差异.
- 根据PIT得分,临床怀孕率的几率比率在ART技术 (ICSI与IMSI,试管婴儿与ICSI) 之间有显著差异.
结论:
- 该PIT得分可以指导选择最有效的ART技术 (IMSI为得分I,ICSI为得分II,IVF/IUI为得分III).
- 这种简化测试有助于为精选的不育夫妇选择最佳的ART策略,可能作为一线治疗.
- 由于统计能力的局限性,需要使用更大的样本规模进行进一步的研究来证实这些发现.
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