瘤芽作为初级结肠癌的预后标志物 - 一个单一的中心体验
Daniela Bajdevska Dukoska1, Panche Zdravkovski1, Slavica Kostadinova-Kunovska1
11Institute of Pathology, Faculty of Medicine, University Ss. Cyril and Methodius, Skopje, RN Macedonia.
概括
在结肠癌 (CC) 中高度瘤芽 (TB) 与较差的患者结局相关. 这种预后因素,瘤芽,应纳入第二阶段和第三阶段CC患者的病理学报告.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 手术瘤学手术瘤学
背景情况:
- 瘤芽 (TB) 是结肠癌 (CC) 的一个公认的形态和预后因素.
- 评估结核病对于了解疾病进展和CC患者的治疗结果至关重要.
研究的目的:
- 为了评估第二阶段和第三阶段结肠癌 (CC) 患者的瘤芽 (TB).
- 确定结核病和临床病理学发现之间的关系.
- 评估结核病在CC的预后价值.
主要方法:
- 对120名在2018-2021年间经过手术的II期和III期CC患者的回顾性分析.
- 在200倍放大时对H&E和CKAE1/AE3染色段进行结核病评估.
- 结核病的分类为低级 (TB1) 和高级 (TB2,TB3).
主要成果:
- 高度结核病与患者年龄,III期结核病,淋巴结状况,血管和淋巴细胞侵袭有显著的相关性.
- 高度结核病患者经历了明显更高的术后复发和死亡率.
- 高度结核病与明显较低的无复发生存率 (RFS) 和整体生存率 (OS) 相关.
- 高度结核病患者的肺和肝转移更频繁.
结论:
- 瘤芽 (TB) 在第二阶段和第三阶段结肠癌 (CC) 中具有显著的预后价值.
- 高度结核病与不良的临床病理特征和较差的生存结果有关.
- 结核病应该作为一个组织学生物标志物被整合到CC患者的病理学报告中.
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