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Updated: Jun 21, 2025

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Assessment of Social Transmission of Food Preferences Behaviors
Published on: January 25, 2018
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社会不利的健康风险可以移植到新的宿主体内
Lucie M Turcotte1, Tao Wang2,3, Kirsten M Beyer4
1Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455.
概括
捐赠者的社会经济状况影响了全原造血细胞移植 (HCT) 后的患者存活率. 低供体SES与HCT受体的生存率降低和死亡率增加有关,突出了健康的社会决定因素.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 社会医学科学 社会医学科学
背景情况:
- 低社会经济地位 (SES) 是已知的死亡率和免疫功能障碍的风险因素.
- 全基性造血细胞移植 (HCT) 转移了血液恶性瘤的健康细胞,这引发了对捐赠者SES对接受者结果的影响的问题.
研究的目的:
- 评估与SES相关的健康风险的移植性.
- 为了确定捐赠者的社会经济地位是否会影响全原造血细胞移植 (HCT) 接受者的健康结果.
主要方法:
- 对2,005名因血液恶性瘤移植的HCT接受者的健康结果的分析.
- 基于细胞捐赠者的社会经济地位 (SES) 的接受者结果的比较,控制其他风险因素.
主要成果:
- 来自最低四分位数SES捐赠者的接受者在整体存活率下降9.7% (P=0.001).
- 在3年内,从最低SES捐赠者的接受者中观察到与治疗相关的死亡率增加6.6% (P=0.008).
- 这些发现表明,与SES相关的效应在细胞转移后仍然存在.
结论:
- 在HCT捐赠者中,社会经济劣势会对接受者生存率和死亡率产生负面影响.
- 这些结果凸显了移植细胞中与SES相关的健康影响的持久性.
- 需要对健康的社会决定因素的生物机制进行进一步的研究,以便为HCT捐赠者和接受者开发干预措施.
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