在90多项研究中,氨基酸负担,白质过强度和海马体积与认知轨迹的关联
Jingxuan Wang1, Sarah Ackley1, Davis C Woodworth1
1From the Department of Epidemiology and Biostatistics (J.W.), University of California, San Francisco; Department of Epidemiology (J.W., S.A., M.M.G.), Boston University, MA; Department of Neurology (D.C.W., S.A.S., C.K., M.M.C.), University of California, Irvine; Imaging of Dementia and Aging Laboratory (C.S.D., E.F.F.), Department of Neurology, University of California, Davis; and Department of Epidemiology and Biostatistics (L.J., M.M.C.), and Department of Neurobiology and Behavior (C.K.), University of California, Irvine.
在老年人中,较高的粉样蛋白负担和较小的海马体积与较低的认知功能和更快的衰退有关. 白质超强度在这个年龄组中没有显著影响认知.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 医疗成像医学成像
背景情况:
- 老年人的认知轨迹受到粉样蛋白病理,血管疾病和中间叶病理的影响.
- 关于这些病理如何影响最老的老年人 (90岁以上) 的认知,目前的证据有限.
研究的目的:
- 评估粉样蛋白负担,白质高强度 (WMH) 体积和海马体积 (HV) 与老年人认知水平和衰退的关联.
主要方法:
- 从90+研究中对192名参与者 (平均年龄92.9岁) 进行了纵向,观察性,基于社区的队列研究.
- 通过MRI通过F-florbetapir PET和HV/WMH体积评估粉样蛋白负载.
- 用MMSE和3MS测试测量认知表现,用线性混合效应模型分析,调整为人口统计和APOE基因型.
主要成果:
- 较高的粉样蛋白负担与较低的认知水平有关 (MMSE,3MS).
- 在HV的1-SD下降与MMSE和3MS得分的显著下降相关.
- 较高的粉样蛋白负担和较小的HV与更快的认知衰退有关;WMH体积没有显著的关联.
结论:
- 粉样蛋白负担和海马缩是最古老的认知水平和衰退的关键预测因素.
- 这些发现澄清了特定病理在老年人认知衰老中的作用.
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