在2型糖尿病患者中,5年多的多神经病变的发展和进展
Peter Kolind Brask-Thomsen1, Mustapha Itani1, Pall Karlsson1
1From the Danish Pain Research Center (P.K.B.-T., P.K., A.G.K., T.S.J., N.B.F., S.S.G.), Department of Clinical Medicine, Aarhus University; Steno Diabetes Center Aarhus (P.K.B.-T., T.S.J.), Aarhus University Hospital; Department of Neurology (M.I., T.K., S.H.S.), Odense University Hospital; Core Center for Molecular Morphology (P.K.), Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University; Department of Clinical Neurophysiology (A.G.K., H.T.), Aarhus University Hospital; Department of Neurophysiology (T.K.), Odense University Hospital; Department of Clinical Research (T.K.), University of Southern Denmark, Odense; Department of Clinical Medicine (H.T.), Aarhus University; and Department of Neurology (N.B.F., S.S.G.), Aarhus University Hospital, Denmark.
糖尿病多神经病变 (DPN) 患病率在5年内在2型糖尿病 (T2D) 患者中增加,主要从可能到确定的DPN. 较高的甘油三与神经病变进展相关.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病多神经病 (DPN) 是2型糖尿病 (T2D) 的常见并发症.
- 了解DPN的自然过程和进展对于有效管理至关重要.
- 这项研究调查了T2D患者中DPN的纵向发展.
研究的目的:
- 检查2型糖尿病 (T2D) 患者在5年内糖尿病多神经病变 (DPN) 的自然过程和发展.
- 通过使用综合性评估,比较DPN随时间变化的表型和诊断变化.
主要方法:
- 一项为期5年的观察性随访队列研究,涉及新诊断的T2D患者和对照.
- 参与者接受了感官表型,定量感官测试 (QST),神经传导研究 (NCS) 和皮肤活检以评估皮内神经纤维密度 (IENFD).
- 根据多伦多的共识标准,DPN被分为可能,可能和确定的阶段.
主要成果:
- 在5年内,确诊的DPN患病率从22.7%增加到33.5%,其中43.9%的可能DPN病例进展为确诊的DPN.
- 神经病变的进展在16.5% (NCS) 和24.7% (IENFD) 观察到,而回归发生在5.9% (NCS) 和18.6% (IENFD).
- 进展与较高的基线腰围和甘油三相关;回归与较低的基线HbA1c相关.
结论:
- 确定的糖尿病多神经病变 (DPN) 的患病率在5年内在2型糖尿病 (T2D) 患者中显著增加.
- 从可能到确定的DPN的进展是这种增长的主要驱动因素.
- 高水平的甘油三与神经病变的进展有关,这表明潜在的危险因素.
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