介绍含有的阴离子三 pentadiene 连接体框架:合成,协调化学和抗真菌活性
Alexander A Sapronov1, Victor N Khrustalev1,2, Olga G Chusova3
1Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, Moscow 117198, Russian Federation.
Inorganic chemistry
|July 15, 2024
概括
研究人员合成了含有的新型阴离子三 pentadiene (SeTAP) 配体及其金属复合物. 这些化合物显示出有前途的抗真菌活性,特别是在对抗植物病原性真菌Phoma eupyrena.
科学领域:
- 无机化学 无机化学 有机化学
- 有机金属化学 有机金属化学
- 药用化学 医学化学
背景情况:
- 带正电荷的配体在化学合成中是罕见的.
- 含的化合物具有独特的电子和结构性质.
- 特里亚zapentadiene框架是多功能联结体支架.
研究的目的:
- 合成和表征含有的新型阴离子三二烯 (SeTAP) 连接物及其金属复合物.
- 研究SeTAP配体及其金属复合物的抗真菌剂潜力.
- 探索这些新化合物的结构和结合特性.
主要方法:
- 通过与NaN(CN) 反应的2-pyridylselenyl试剂合成复合物2.2.
- 转金属化反应以制备各种金属-SeTAP复合物 (Cu,Ag,Au,Fe).
- 密度函数理论 (DFT) 计算用于结构和结合分析.
- 在体外查抗真菌活性对植物病原菌的查.
主要成果:
- 成功合成了前所未有的含有的阴离子三 pentadiene (SeTAP) 连接体框架及其复合体.
- 易于通过转基法制备各种金属-SeTAP复合物.
- DFT分析证实了固态中素结合相互作用.
- 观察到显著的体外抗真菌活性,具有显著的敏感性 *Phoma eupyrena*.
结论:
- 这项研究报告了第一个聚酸SeTAP配体及其金属复合物的合成.
- 这些SeTAP金属复合体显示出抗真菌应用的潜力.
- 这些发现有助于开发具有生物活性的基于的新型化合物.
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