开发气管替代品的挑战和机会,以恢复长段缺陷的气管替代品
Kausik Kapat1, Prashil Gondane1, Sakshi Kumbhakarn1
1Department of Medical Devices, National Institute of Pharmaceutical Education and Research Kolkata, 168, Maniktala Main Road, Kankurgachi, Kolkata, West Bengal, 700054, India.
Macromolecular bioscience
|July 15, 2024
概括
气管重建使用组织工程来创建生物相容的替代品,以应对严重的气道堵塞. 目前面临的挑战包括移植的强度,愈合和预防复原,需要进一步的研究才能有效地临床应用.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 手术创新 在外科创新.
背景情况:
- 由于受伤,瘤或狭窄造成的气管缺陷需要进行手术重建.
- 气管替代品对于超过50%的成人和30%的儿童缺陷至关重要.
- 组织工程提供了有前途的生物相容性气管替代品,模仿本地气管.
研究的目的:
- 审查气管缺陷的重建和再生技术.
- 讨论气替代品的设计标准.
- 为了探索制造方法和挑战在气管移植的发展.
主要方法:
- 对气管重建和组织工程的当前文献的综述.
- 对气管移植的各种生物材料 (聚合物,生物金属) 的分析.
- 检查表面修改技术以提高生物相容性.
主要成果:
- 组织工程气管替代品显示出希望,但面临临临床局限性.
- 挑战包括机械强度不足,重新上皮质化不良和血管化.
- 静脉炎仍然是气管缺陷愈合的重要障碍.
结论:
- 由于移植材料的局限性,气管缺陷的完全治愈具有挑战性.
- 需要在接种制造和表面修改方面取得进一步的进展.
- 优化机械强度和生物整合是成功气管再生的关键.
相关概念视频
Trachea
1.8K
The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
1.8K
Tracheostomy Decannulation
148
Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
148
Tracheostomy: Procedure and Tubes
507
A tracheostomy is a surgical procedure that creates an artificial opening into the trachea, typically at the second or third cartilaginous ring level. This opening allows the insertion of a tracheostomy tube, which can replace an endotracheal tube, provide mechanical ventilation, bypass an upper airway obstruction, or remove accumulated tracheobronchial secretions.
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
507
Oxygen Delivering System III: Tracheostomy and T-piece
740
Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
740
Flail Chest-II
161
Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:
Assessment:
1. Clinical Evaluation:
History:
161
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
488
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
488


