儿童开始的系统性红血性狼的长期结果
Anne Mirguet1,2, Florence A Aeschlimann3, Irene Lemelle4
1Department of Pediatric Nephrology, Children Hospital, University Hospital of Nancy, Lorraine University, Vandoeuvre-lès-Nancy, France.
Rheumatology (Oxford, England)
|July 15, 2024
概括
儿童发作的全身性红斑狼 (cSLE) 的长期结果显示,器官损伤和活跃疾病的持续高率. 撒哈拉以南非洲的种族与这些患者活跃疾病的几率增加有关.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 系统性红斑狼 (SLE) 是一种
- 自免疫性疾病 自免疫性疾病
背景情况:
- 儿童发病SLE (cSLE) 的长期结果数据有限.
- 了解长期后果对于管理这种慢性疾病至关重要.
研究的目的:
- 描述患有cSLE的患者的长期结果.
- 为了确定与疾病损伤和持续活动相关的因素.
主要方法:
- 使用PEDIALUP注册表中的数据进行了回顾性多中心研究.
- 从医疗记录中收集人口统计,临床,实验室,放射学,组织学和治疗数据.
主要成果:
- 138名cSLE患者被随访了平均15.4年.
- 51%的人有累积损伤 (SLICC-DI ≥1),随随访持续时间而增加.
- 34%的人患有活跃疾病 (SLEDAI ≥6);撒哈拉以南非洲族裔与7倍增加的几率有关.
结论:
- 在cSLE患者中,损伤的高患病率仍然存在,即使是最近的诊断.
- 随访时间和种族是长期结果的重要因素.
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