在COVID-19后接受肺部康复的患者中,支气管扩展剂反应
Simon Alexander Krooss1,2,3, Isabel Klefenz4, Michael Ott1
1Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Respiration; international review of thoracic diseases
|July 15, 2024
概括
后COVID-19患者经常经历持续的呼吸系统问题. 这项研究发现阻塞性呼吸系统缺陷和支气管扩展器反应增加,这表明适应性吸入治疗对持续症状的潜在益处.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- SARS-CoV-2 感染可以导致各种各样的症状,但对肺功能的长期影响尚不清楚.
- 持续的呼吸道症状,如疲劳性呼吸不全,在COVID-19后的患者中很常见.
研究的目的:
- 在SARS-CoV-2感染后经历持续症状的患者中调查支气管扩展剂反应.
- 评估该患者队列中阻塞性呼吸系统缺陷的流行率.
主要方法:
- 检查了134名COVID-19后患者,在炼时出现持续性呼吸障碍.
- 评估了使用β2-上腺激动剂的支气管扩展剂反应.
- 将结果与历史对照组进行比较,并根据住院状态分析差异.
主要成果:
- 支气管扩张后观察到FEV1 (181.5毫升) 的平均显著增加,高于对照组 (118毫升).
- 4.47%的患者最初出现了阻塞性呼吸道疾病 (FEV1/FVC比率低于正常).
- 28.7%的FEV1增加超过200毫升,12%的患者表现出显著的支气管扩张反应;住院和非住院患者之间没有差异.
结论:
- 患有持续症状的COVID-19后患者表现出阻塞性呼吸系统缺陷和支气管扩展剂反应率的增加.
- 适应的β2吸入治疗可能有利于患有这些并发症的患者.
- 为管理COVID-19后的呼吸系统问题,建议进一步重新评估.
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