在大麻使用后,在呼出的呼吸凝结物中检测到的大麻素
Jennifer L Berry1, Ashley Brooks-Russell2, Cheryle N Beuning1
1Applied Chemical and Materials Division, National Institute of Standards and Technology, 325 Broadway, Boulder, CO, United States of America.
Journal of breath research
|July 15, 2024
概括
呼出的呼吸凝聚物 (EBC) 显示出最近使用大麻的潜力,在使用后不久的所有样本中都发现了THC. 需要进一步的研究来优化EBC分析以可靠地检测大麻.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在呼吸中检测大麻是具有挑战性的,因为现有的以气溶为基础的方法缺乏确定最近使用的可靠性.
- 呼出的呼吸凝聚物 (EBC),一种水性基质,对于大麻素检测仍然未被探索.
- 了解EBC中的大麻素存在对于开发用于大麻使用监测的新方法至关重要.
研究的目的:
- 研究出口呼吸凝结物 (EBC) 作为检测大麻消费后大麻素的矩阵的潜力.
- 为了监测在使用大麻后的不同时间点收集的EBC样本中,包括THC在内的11种不同大麻素的存在和度.
主要方法:
- 在观察到大麻使用之前和在观察到大麻使用后的两个时间点 (0.7小时和1.7小时) 从参与者身上收集了EBC.
- 利用液体染色学并联质谱法 (LC-MS/MS) 来量化11种大麻素.
- 分析THC和其他大麻素度与样本指标相关.
主要成果:
- 在大麻使用者的EBC中检测到五种大麻素,包括delta-9-tetrahydrocannabinol (THC).
- 在使用后0.7小时收集的所有EBC样本中都存在THC,减少了1.7小时.
- 非THC类大麻素仅在大麻消费后被检测到,而THC也在一些使用前样本中被发现.
结论:
- EBC是检测最近使用大麻,特别是THC的有希望的矩阵.
- 进一步调查EBC采样设备,各种大麻使用模式和使用后的时间点是有必要的.
- 从EBC中优化大麻素回收对于提高检测可靠性至关重要.
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